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Janumet may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or irregular heart rate, dizziness, or feeling very weak or tired.

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Call your doctor at once if you have any of these serious side effects:

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• feeling short of breath (even with mild exertion) swelling or rapid weight gain; or
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Less serious this side effects may include:

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